At Quell we seek to deliver truly innovative, life-changing therapies for our patients. Our vision as a company is to build a major global biopharmaceutical company bringing transformational and valued therapies for a range of autoimmune and inflammatory diseases, as well as preventing rejection in organ transplantation, based on modular engineered Tregs. 

OUR COMPANY

Quell Therapeutics Ltd (“Quell”), the world leader in the development of engineered T-regulatory (Treg) cell therapies for serious medical conditions driven by the immune system, announced it has raised $156 million in an oversubscribed Series B financing. The financing round was co-led by Jeito Capital, Ridgeback Capital Investments, SV Health Investors and Fidelity Management & Research Company LLC with participation from founding investor Syncona. New investors include British Patient Capital through its Future Fund: Breakthrough program, Janus Henderson Investors, Monashee Investment Management, Point72 and funds managed by Tekla Capital Management LLC

Fantastic collaborative environment at Translation & Innovation Hub - White City, London, and Guys and St Thomas Trust, London. Investment including brand new lab equipment, innovative methods, and exposure to cutting edge technology.

THE ROLE

Quell is looking for a Senior Research Associate to join our R&D Team This individual will be involved in different projects aiming to identify and characterize the next generation of Quell CAR Treg products. The ideal candidate will be skilled in both molecular biology techniques and immune cell based assays. They will work closely with scientists within the same group and help with experiments, analyse data, and present findings. The Senior RA will be also supporting other groups in R&D to develop our future products.

This position offers an excellent opportunity for a talented and motivated scientist to contribute to a growing pipeline of assets in an exciting and highly dynamic environment focused on developing cutting-edge cellular therapies.

MAIN RESPONSIBILITIES

• Design, develop and perform cell-based assays to evaluate engineered immune cell function with minimal supervision.
• Design and execute in vitro studies utilizing primary or immortalized immune cells.
• Perform multi-colour flow cytometry-based characterization of immune cells.
• Design and clone novel chimeric antigen receptors with minimal supervision.
• Ability to be involved in multiple projects and cross-functional work.
• Ability to analyse experimental results and recommend subsequent experiments
• Collaborate with technical experts for assay setup, protocol optimisation and troubleshooting.
• Maintain highly organised and detailed documentation of experimental procedures and assist in establishing relevant SOPs.
• Collaborate and coordinate work with other teams to meet deadlines and goals.
• Stay up-to-date with literature and new technologies within the cell therapy field.
• Help to maintain the laboratories to a high standard.
• Manage databases and assist in establishing relevant SOPs
• Provide guidance and training to new or junior staff.
• Complies with standard lab practices and company policies

SKILLS & EXPERIENCE

Experience & Technical Requirements – Essential (E), Preferred (P)

• Solid understanding of cell biology. E
• Competent understanding of immunology. E
• Solid understanding of T-cell biology. P
• Competent handling of mammalian and primary human immune cell cultures using aseptic techniques. E
• Good understanding of and skilled with multi-parameter Flow Cytometry. E
• Familiarity with data analysis software such as Prism, FlowJo and/or FCS express. E
• Experience with immunological cell-based assays. E
• Understanding of process optimisation and assay development. P
• Ability to efficiently identify and implement solutions. P
• Excellent organisational skills to adhere to deadlines and reach goals. E
• Excellent time and project management skills aligned with an ability to prioritise activities. P
• Ability to work co-operatively as part of a team as well as independently. E
• Professional and personable communication skills. E
• Good attention to detail and record keeping. E
• Previous experience using electronic lab notebooks. P
• Proven commitment to high quality work and maintenance of high standards. P
• Willingness to contribute to a culture that embraces scientific excellence, integrity, urgency, patient centricity, and continuous improvement. E