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Senior Scientist - Vector Processing

Location: White City, London, UK

Salary: Negotiable

About us

At Quell we seek to deliver truly innovative, life-changing therapies for our patients. Our vision as a company is to build a major global biopharmaceutical company bringing transformational and valued therapies for a range of autoimmune and inflammatory diseases, as well as preventing rejection in organ transplantation, based on modular engineered Tregs.

 

Our Company

Quell was founded in March 2019 in partnership with six prominent immunological experts from King’s College London, University College London, and Hannover Medical School, and is led by Iain McGill, a leading pharmaceutical executive with extensive relevant experience, having spent most of his 25 years in the industry in immunology, including the areas of solid organ and cell transplantation. The Company was founded with initial series A financing, led by Syncona Ltd who committed £34M with a further £1M contributed by UCL Technology Fund.

 

The Role

This role is in the CMC Vector Processing team, which is responsible for the production, purification, and analysis of lentiviral vectors (LV) at Quell. The vector processing team are responsible for the production of LV for process development activities as well as GMP vector for used in the manufacture of Quell’s CAR Treg therapies.

This role covers a wide range of activities from upstream and downstream production of LV, as well as the analysis of the materials produced and testing of the LV functionality on Tregs. The person will need to be able to work with their CMC colleagues in the Cell Processing, Analytical and QC departments as well as with colleagues from R&D.

Main Responsibilities
  • Development of process for the production and purification of lentiviral vectors
  • Development of methods for the analysis and characterisation of lentiviral vectors and contaminants
  • Delivering batches of lentiviral vector to support process research and development activities
  • Working with CDMOs to deliver lentiviral vectors to support development and manufacturing activities

 

Experience we are looking for
  • Experience of production and or purification of lentiviral vector at lab, pilot plant or manufacturing scale
  • In depth knowledge of key analytical methods used for lentiviral vector analysis and characterisation
  • Experience of analytical methods used for key contaminant analysis and replication competency
  • Demonstrated ability in viral vector process development and tech transfer to CDMO’s
  • Evidence and/or practical experience of GMP manufacturing of viral vectors and or plasmids
  • Knowledge or experience of formulation and filling of viral vectors and or plasmid DNA
  • Sound knowledge of DoE methodologies and their application to process development and characterisation

 

Technical Skills required
  • Expression of viral vectors using HEK293 cells in adherent and suspension systems at laboratory, pilot, or manufacturing scale
  • Sound knowledge of FACS and q/dPCR methods for viral vector titration and vector copy number determination
  • Purification of viral vectors from adherent and/or suspension systems at laboratory, pilot or manufacturing scale
  • Development of analytical and characterisation methods for viral vectors and key contaminants

 

Personal qualities
  • Ability to work collaboratively within a team, supporting one another and held accountable for project deliverables
  • Professional and personable communication skills within a close-knit team and senior stakeholders of the business
  • Driven to solve problems pragmatically in an innovate way
  • Take pride and respect in leading a team effectively and efficiently
  • Desire to work with integrity and act as an ambassador for Quell and the wider business

 

Benefits
  • Holidays: 25 days per year
  • Life Assurance: 4 x base salary
  • Group Personal Pension: Auto enrolled at 4% employer contribution, 4% employee contribution
  • Private Medical Insurance for your whole family
  • Annual Bonus

 

Perks
  • Fantastic collaborative environment at Translation & Innovation Hub
  • £36 Million Investment including brand new lab equipment, innovative methods, and exposure to cutting edge technology
  • Flexible working
  • Fast paced and progressive company looking for future leaders and innovators

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