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Scientist II – Research Method Development

Location: White City, London

ABOUT US

At Quell we seek to deliver truly innovative, life-changing therapies for our patients. Our vision as a company is to build a major global biopharmaceutical company bringing transformational and valued therapies for a range of autoimmune and inflammatory diseases, as well as preventing rejection in organ transplantation, based on modular engineered Tregs.

 

OUR COMPANY

Quell was founded in March 2019 in partnership with six prominent immunological experts from King’s College London, University College London, and Hannover Medical School, and is led by Iain McGill, a leading pharmaceutical executive with extensive relevant experience, having spent most of his 25 years in the industry in immunology, including the areas of solid organ and cell transplantation. The Company was founded with initial series A financing, led by Syncona Ltd who committed £34M with a further £1M contributed by UCL Technology Fund.

 

 

THE ROLE

Scientist II – Research Method Development Team

Quell is looking for a Scientist II to join the Research Method Development team. This individual will report to the Associate Director of Product Research and will help to develop new assays and optimise current processes. The Method Development team provides a key function to transfer knowledge and activities between the R&D and CMC departments. The successful candidate will work closely with the other sub-teams within Product Research to conduct experiments, analyse data, and present findings. They will also collaborate with other teams in R&D and CMC to progress our understanding of our cellular products.

 

This position offers an excellent opportunity for a talented and motivated Scientist II to contribute to a key part of our work. Quell offers an exciting and highly dynamic environment focused on developing cutting-edge Treg therapies.

 

 

MAIN RESPONSIBILITIES

  • Design, develop and optimise methods for Product Research.
  • Perform immunological cell-based assays.
  • Provide scientific expertise for assay development and technical expertise for optimisation and troubleshooting.
  • Critically analyse data in a timely manner and present findings at team/departmental meetings.
  • Maintain highly organised and detailed documentation of experimental procedures and assist in establishing relevant SOPs.
  • Collaborate and coordinate work with other teams to meet deadlines and goals.
  • Transfer of methods and assays to other teams.
  • Stay up-to-date with literature and new technologies within the cell therapy field.
  • Help to maintain the laboratories to a high standard.
  • Provide guidance and training to new or junior staff.

 

 

ESSENTIAL SKILLS AND EXPERIENCE

  • Solid understanding of T-cell biology.
  • Good understanding of immunology.
  • Demonstrable experience with assay development and process optimisation.
  • Competent handling of mammalian and primary human immune cell cultures using aseptic techniques.
  • Demonstrable experience with immunological cell-based assays.
  • Solid understanding of and skilled with multi-parameter Flow Cytometry.
  • Demonstrable experience with building large (15+ colour) Flow Cytometry panels.
  • Familiarity with data analysis softwares such as Prism and FlowJo.
  • Excellent organisational skills to adhere to deadlines and reach goals.
  • Work co-operatively as part of a team as well as independently.
  • Good attention to detail and record keeping.
  • PhD in Immunology or related subject and 3 year of relevant industry experience.

 

 

DESIRED SKILLS AND EXPERIENCE

  • Solid understanding of Treg biology.
  • Experience with the use of the Cytek Aurora and NxT Attune flow cytometers.
  • Excellent time and project management skills aligned with an ability to prioritise activities.
  • Ability to efficiently identify and implement solutions.
  • Previous experience using electronic lab notebooks.
  • Proven commitment to high quality work and maintenance of high standards.
  • Contribute to a culture that embraces scientific excellence, integrity, urgency, patient centricity and continuous improvemen

 

 

PERSONAL QUALITIES

  • Ability to work collaboratively within a team, supporting one another and held accountable for project deliverables.
  • Professional and personable communication skills.
  • Driven to solve problems pragmatically.
  • Passionate about science.
  • Good working attitude, reliability, and flexibility.
  • Desire to work with integrity and act as an ambassador for Quell and the wider business.

 

 

BENEFITS

  • Holidays: 25 days per year.
  • Life Assurance: 4 x base salary.
  • Group Personal Pension: Auto enrolled at 4% employer contribution, 4% employee contribution.
  • Private Medical Insurance for your whole family.
  • Annual Bonus.

 

 

PERKS

  • Fantastic collaborative environment at Translation & Innovation Hub
  • £36 Million Investment including brand new lab equipment, innovative methods, and exposure to cutting edge technology.
  • Flexible working.
  • Fast paced and progressive company looking for future leaders and innovators.

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